Brain Dev. 2010 Sep;32(8):691-4. Epub 2009 Nov 14.

A case of D-lactic acid encephalopathy associated with use of probiotics.

Munakata S, Arakawa C, Kohira R, Fujita Y, Fuchigami T, Mugishima H.

Source

Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan. shun-m@jb3.so-net.ne.jp

Abstract

A five year old girl was admitted to the hospital for evaluation of intermittent ataxia. She had undergone serial resections of the small intestine after birth, resulting in short bowel syndrome. Lactomin was prescribed for watery diarrhea at twice the regular dose 2 weeks before the onset of neurologic symptoms. D-lactic acidosis was diagnosed on the basis of a plasma D-lactate level of 5.537 mmol/l. Lactomin was discontinued, and she was treated with sodium bicarbonate and oral antibiotics. The probiotics the patient had taken were likely the cause of D-lactic acidosis and should therefore be avoided in patients with short bowel syndrome.

PMID:: 19917522; [PubMed - indexed for MEDLINE]

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