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J Am Chem Soc. 2010 Feb 10;132(5):1452-3. doi: 10.1021/ja907690g.

Ultrafast dynamics of protein proton transfer on short hydrogen bond potential energy surfaces: S65T/H148D GFP.

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  • 1School of Chemistry, University of East Anglia, Norwich NR4 7TJ, UK.


Ultrafast proton transfer dynamics on a short H-bond in a protein were studied through the time-resolved fluorescence of the S65T/H148D green fluorescent protein (GFP) mutant. In response to the change in chromophore pK(a) upon excitation, the donor-proton-acceptor structure evolves on a sub-100 fs time scale, followed by picosecond time scale vibrational cooling and host structure reorganization.

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