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Nat Immunol. 2009 Dec;10(12):1237-44. doi: 10.1038/ni.1822. Epub 2009 Nov 16.

Dendritic cell subsets in primary and secondary T cell responses at body surfaces.

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  • 1The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.


We examine the role of dendritic cells subsets in immunity to peripheral infections, with emphasis on the differences in the regulation of primary and secondary T cell responses to viruses. Our major focus is on new developments in the understanding of immunity to infections of the skin and lung, which are crucial entry points for a variety of infectious pathogens. Initially we describe a diverse network of dendritic cell subsets, but then we argue for a more generalized model of reduced complexity.

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