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Nat Immunol. 2009 Dec;10(12):1237-44. doi: 10.1038/ni.1822. Epub 2009 Nov 16.

Dendritic cell subsets in primary and secondary T cell responses at body surfaces.

Author information

  • 1The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia. wrheath@unimelb.edu.au

Abstract

We examine the role of dendritic cells subsets in immunity to peripheral infections, with emphasis on the differences in the regulation of primary and secondary T cell responses to viruses. Our major focus is on new developments in the understanding of immunity to infections of the skin and lung, which are crucial entry points for a variety of infectious pathogens. Initially we describe a diverse network of dendritic cell subsets, but then we argue for a more generalized model of reduced complexity.

PMID:
19915624
[PubMed - indexed for MEDLINE]
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