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Indian J Dermatol Venereol Leprol. 2009 Nov-Dec;75(6):579-82. doi: 10.4103/0378-6323.57718.

Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.

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  • 1Dr. Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India. samarpan_research@yahoo.co.in

Abstract

BACKGROUND:

Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians.

AIM:

To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.

METHODS:

Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.

RESULTS:

Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.

CONCLUSION:

This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.

PMID:
19915237
[PubMed - indexed for MEDLINE]
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