Minerva Med. 2009 Oct;100(5):371-83.

Decisions and ethical issues among BRCA carriers and the use of preimplantation genetic diagnosis.

Quinn GP, Vadaparampil ST, Bower B, Friedman S, Keefe DL.

Source

Moffitt Cancer Center and Research Institute, Division of Cancer Prevention and Control, Tampa, FL, USA. gwen.quinn@moffitt.org

Abstract

The lifetime risks for both breast and ovarian cancer for BRCA mutation carriers far exceeds the general population risk of 13% for breast cancer and 1.4% for ovarian cancer. BRCA carriers have unique and medically complicated decisions to make regarding their cancer treatment or risk reduction. As BRCA testing becomes increasingly common among unaffected individuals in families with a previously documented BRCA mutation, there are a growing number of individuals with unique psychosocial needs and concerns. This review paper describes the BRCA 1/2 population, discusses preimplantation genetic diagnosis (PGD), and describes the decisions and ethical issues related to PGD among the BRCA 1/ 2 population.

PMID:: 19910890; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Minerva Medica - PDF

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Opinion about reproductive decision making among individuals undergoing BRCA1/2 genetic testing in a multicentre Spanish cohort. [Hum Reprod. 2009]
Opinion about reproductive decision making among individuals undergoing BRCA1/2 genetic testing in a multicentre Spanish cohort.
Fortuny D, Balmaña J, Graña B, Torres A, Ramón y Cajal T, Darder E, Gadea N, Velasco A, López C, Sanz J, et al. Hum Reprod. 2009 Apr; 24(4):1000-6. Epub 2008 Dec 26.
Ethical, legal and social implications of prenatal and preimplantation genetic testing for cancer susceptibility. [Reprod Biomed Online. 2009]
Ethical, legal and social implications of prenatal and preimplantation genetic testing for cancer susceptibility.
Wang CW, Hui EC. Reprod Biomed Online. 2009; 19 Suppl 2:23-33.
Views of BRCA gene mutation carriers on preimplantation genetic diagnosis as a reproductive option for hereditary breast and ovarian cancer. [Hum Reprod. 2007]
Views of BRCA gene mutation carriers on preimplantation genetic diagnosis as a reproductive option for hereditary breast and ovarian cancer.
Menon U, Harper J, Sharma A, Fraser L, Burnell M, ElMasry K, Rodeck C, Jacobs I. Hum Reprod. 2007 Jun; 22(6):1573-7. Epub 2007 Apr 11.
Review Psychosocial issues associated with genetic testing for breast and ovarian cancer risk: an integrative review. [Cancer Invest. 2003]
Review Psychosocial issues associated with genetic testing for breast and ovarian cancer risk: an integrative review.
Pasacreta JV. Cancer Invest. 2003; 21(4):588-623.
Review Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: systematic evidence review for the U.S. Preventive Services Task Force. [Ann Intern Med. 2005]
Review Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: systematic evidence review for the U.S. Preventive Services Task Force.
Nelson HD, Huffman LH, Fu R, Harris EL, U.S. Preventive Services Task Force. Ann Intern Med. 2005 Sep 6; 143(5):362-79.

See reviews... See all...

Cited by 1 PubMed Central article

The GAMY Project: young people's attitudes to genetics in the South Wales valleys. [Hugo J. 2010]
The GAMY Project: young people's attitudes to genetics in the South Wales valleys.
Iredale R, Madden K, Taverner N, Yu J, McDonald K. Hugo J. 2010 Dec; 4(1-4):49-60. Epub 2011 Jan 11.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Decisions and ethical issues among BRCA carriers and the use of preimplantation ...
Decisions and ethical issues among BRCA carriers and the use of preimplantation genetic diagnosis.
Minerva Med. 2009 Oct ;100(5):371-83.

PubMed
Midlife fruit and vegetable consumption and risk of dementia in later life in Sw...
Midlife fruit and vegetable consumption and risk of dementia in later life in Swedish twins.
Am J Geriatr Psychiatry. 2010 May ;18(5):413-20.

PubMed
Evidence supporting balance training in healthy individuals: a systemic review.
Evidence supporting balance training in healthy individuals: a systemic review.
J Strength Cond Res. 2009 Dec ;23(9):2718-31.

PubMed
Presbyopia-correcting intraocular lenses: 'one lens does not fit all'.
Presbyopia-correcting intraocular lenses: 'one lens does not fit all'.
Curr Opin Ophthalmol. 2010 Jan ;21(1):1-3.

PubMed
The surgical management of sacral chordomas.
The surgical management of sacral chordomas.
Spine (Phila Pa 1976). 2009 Nov 15 ;34(24):2700-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Decisions and ethical issues among BRCA carriers and the use of preimplantation genetic diagnosis.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information