AJNR Am J Neuroradiol. 2010 May;31(5):880-1. Epub 2009 Nov 12.

White matter lesions suggestive of amyotrophic lateral sclerosis attributed to celiac disease.

Brown KJ, Jewells V, Herfarth H, Castillo M.

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Department of Radiology, University of North Carolina, Chapel Hill, North Carolina 27599-7510, USA. kelanbrown@gmail.com

Abstract

CD is an autoimmune-mediated disorder of the gastrointestinal tract. Initial symptom presentation is variable and can include neurologic manifestations that may comprise ataxia, neuropathy, dizziness, epilepsy, and cortical calcifications rather than gastrointestinal-hindering diagnosis and management. We present a case of a young man with progressive neurologic symptoms and brain MR imaging findings worrisome for ALS. During the diagnostic work-up, endomysium antibodies were discovered, and CD was confirmed by upper gastrointestinal endoscopy with duodenal biopsies. MR imaging findings suggestive of ALS improved after gluten-free diet institution.

PMID:: 19910450; [PubMed - indexed for MEDLINE]

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White matter lesions suggestive of amyotrophic lateral sclerosis attributed to celiac disease.

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