Immunol Rev. 2009 Nov;232(1):240-54.

The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B.

Lapinski PE, Oliver JA, Bodie JN, Marti F, King PD.

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Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5620, USA.

Abstract

Adapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T-cell antigen receptor signal transduction is well established. An exception to this is the family of T-cell-specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T-cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed.

PMID:: 19909368; [PubMed - indexed for MEDLINE]

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