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Biochem Soc Trans. 2009 Dec;37(Pt 6):1248-53. doi: 10.1042/BST0371248.

Regulation of angiogenesis by ETS transcription factors.

Author information

  • 1National Heart and Lung Institute (NHLI) Cardiovascular Sciences Unit, Hammersmith Hospital, Imperial College London, London W12 0NN, UK. a.randi@imperial.ac.uk

Abstract

Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally, we discuss novel evidence that shows how these transcription factors act in a combinatorial fashion with others, through composite sites that may be crucial in determining endothelial specificity in gene transcription.

PMID:
19909256
[PubMed - indexed for MEDLINE]
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