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Cardiovasc J Afr. 2009 Sep-Oct;20(5):296-9.

The effect of sympathomimetic medication on cardiovascular functioning of children with attention-deficit/hyperactivity disorder.

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  • 1Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria.

Abstract

OBJECTIVE:

The aim of this study was to investigate the effects of sympathomimetic medication on the cardiovascular system of children with attention-deficit/hyperactivity disorder (ADHD).

METHODS:

Cardiovascular functioning of children with ADHD (n = 19) was tested while the children were stimulant free and during a period in which they were on stimulant medication. Electrocardiograms (ECGs) were obtained by means of a Schiller CardioLaptop AT-110 ECG recorder using the standard 12-lead cable positioning for a resting ECG. Blood pressure was measured by means of a stethoscope and mercury sphygmomanometer.

RESULTS:

The main findings of this study were that methylphenidate usage is associated with increases in heart rate (HR) and blood pressure (BP), and that it does not adversely affect HR-corrected QT and JT intervals or cardiac dispersion values.

CONCLUSION:

Methylphenidate causes an increase in HR as well as increases in both systolic and diastolic BP, but no change in cardiac depolarisation and repolarisation duration or homogeneity.

PMID:
19907802
[PubMed - indexed for MEDLINE]
PMCID:
PMC3721264
Free PMC Article
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