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Acta Haematol. 2009;122(2-3):78-86. doi: 10.1159/000243791. Epub 2009 Nov 10.

The role of hepcidin in iron metabolism.

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  • 1David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. enemeth@mednet.ucla.edu

Abstract

Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory.

Copyright 2009 S. Karger AG, Basel.

PMID:
19907144
[PubMed - indexed for MEDLINE]
PMCID:
PMC2855274
Free PMC Article
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