Curr Biol. 2009 Sep 15;19(17):R790-9.

Biology and physics of cell shape changes in development.

Source

Max-Planck-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. paluch@mpi-cbg.de

Abstract

Together with cell growth, division and death, changes in cell shape are of central importance for tissue morphogenesis during development. Cell shape is the product of a cell's material and active properties balanced by external forces. Control of cell shape, therefore, relies on both tight regulation of intracellular mechanics and the cell's physical interaction with its environment. In this review, we first discuss the biological and physical mechanisms of cell shape control. We next examine a number of developmental processes in which cell shape change - either individually or in a coordinated manner - drives embryonic morphogenesis and discuss how cell shape is controlled in these processes. Finally, we emphasize that cell shape control during tissue morphogenesis can only be fully understood by using a combination of cellular, molecular, developmental and biophysical approaches.

PMID:: 19906581; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review Interplay of mechanical deformation and patterned gene expression in developing embryos. [Curr Opin Genet Dev. 2004]
Review Interplay of mechanical deformation and patterned gene expression in developing embryos.
Brouzés E, Farge E. Curr Opin Genet Dev. 2004 Aug; 14(4):367-74.
The forces that shape embryos: physical aspects of convergent extension by cell intercalation. [Phys Biol. 2008]
The forces that shape embryos: physical aspects of convergent extension by cell intercalation.
Keller R, Shook D, Skoglund P. Phys Biol. 2008 Apr 10; 5(1):015007. Epub 2008 Apr 10.
Review Compartmentalized morphogenesis in epithelia: from cell to tissue shape. [Dev Dyn. 2005]
Review Compartmentalized morphogenesis in epithelia: from cell to tissue shape.
Pilot F, Lecuit T. Dev Dyn. 2005 Mar; 232(3):685-94.
Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. [Development. 2006]
Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila.
Köppen M, Fernández BG, Carvalho L, Jacinto A, Heisenberg CP. Development. 2006 Jul; 133(14):2671-81.
Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. [J Cell Biol. 2000]
Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila.
Kiehart DP, Galbraith CG, Edwards KA, Rickoll WL, Montague RA. J Cell Biol. 2000 Apr 17; 149(2):471-90.

See reviews... See all...

Cited by 3 PubMed Central articles

There is more than one way to turn a spherical cellular monolayer inside out: type B embryo inversion in Volvox globator. [BMC Biol. 2011]
There is more than one way to turn a spherical cellular monolayer inside out: type B embryo inversion in Volvox globator.
Höhn S, Hallmann A. BMC Biol. 2011 Dec 29; 9:89. Epub 2011 Dec 29.
Cell-ECM traction force modulates endogenous tension at cell-cell contacts. [Proc Natl Acad Sci U S A. 2011]
Cell-ECM traction force modulates endogenous tension at cell-cell contacts.
Maruthamuthu V, Sabass B, Schwarz US, Gardel ML. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4708-13. Epub 2011 Mar 7.
Coaction of intercellular adhesion and cortical tension specifies tissue surface tension. [Proc Natl Acad Sci U S A. 2010]
Coaction of intercellular adhesion and cortical tension specifies tissue surface tension.
Manning ML, Foty RA, Steinberg MS, Schoetz EM. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12517-22. Epub 2010 Jun 28.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Biology and physics of cell shape changes in development.
Biology and physics of cell shape changes in development.
Curr Biol. 2009 Sep 15 ;19(17):R790-9.

PubMed
The shape of motile cells.
The shape of motile cells.
Curr Biol. 2009 Sep 15 ;19(17):R762-71.

PubMed
Investigating alternative acidic proteases for H/D exchange coupled to mass spec...
Investigating alternative acidic proteases for H/D exchange coupled to mass spectrometry: plasmepsin 2 but not plasmepsin 4 is active under quenching conditions.
J Am Soc Mass Spectrom. 2010 Jan ;21(1):76-9. Epub 2009 Sep 17 .

PubMed
Omega-3 polyunsaturated fatty acids and anxiety disorders.
Omega-3 polyunsaturated fatty acids and anxiety disorders.
Prostaglandins Leukot Essent Fatty Acids. 2009 Nov-Dec ;81(5-6):309-12. Epub 2009 Nov 10 .

PubMed
The 844ins68 polymorphism of the cystathionine beta-synthase gene is associated ...
The 844ins68 polymorphism of the cystathionine beta-synthase gene is associated with schizophrenia.
Psychiatry Res. 2009 Dec 30 ;170(2-3):168-71. Epub 2009 Nov 10 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: