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Curr Biol. 2009 Sep 15;19(17):R762-71. doi: 10.1016/j.cub.2009.06.053.

The shape of motile cells.

Author information

  • 1Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA. mogilner@math.ucdavis.edu

Abstract

Motile cells - fan-like keratocytes, hand-shaped nerve growth cones, polygonal fibroblasts, to name but a few - come in different shapes and sizes. We discuss the origins of this diversity as well as what shape tells us about the physics and biochemistry underlying cell movement. We start with geometric rules describing cell-edge kinetics that govern cell shape, followed by a discussion of the underlying biophysics; we consider actin treadmilling, actin-myosin contraction, cell-membrane deformations, adhesion, and the complex interactions between these modules, as well as their regulation by microtubules and Rho GTPases. Focusing on several different cell types, including keratocytes and fibroblasts, we discuss how dynamic cell morphology emerges from the interplay between the different motility modules and the environment.

PMID:
19906578
[PubMed - indexed for MEDLINE]
PMCID:
PMC2864320
Free PMC Article

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