Infection. 2010 Feb;38(1):69-72. Epub 2009 Nov 10.

Interferon-gamma release assay in the ascites: Early hint for diagnosis of abdominal tuberculosis.

Lorenz R, Würl P, Haerter G, Cammerer G, Barth T, Hausladen S, Stenger S, Kern P.

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Dept. of Internal Medicine, University Hospital Ulm, Germany. Richard.Lorenz@uniklinik-ulm.de

Abstract

We report on a 20-year-old woman with abdominal tuberculosis.Standard microbiological examination of ascites showed no acid-fast bacilli (AFB), and analysis for the Mycobacterium tuberculosis (MTB)-complex DNA by PCR was negative. However,the interferon-gamma release assay (IGRA) of the ascites was positive after specific stimulation with mycobacterial antigens(ESAT-6/CFP-10/TB7.7[p4]), indicating an infection with MTB.The diagnosis of tuberculosis was later confirmed by histology, MTB culture, and PCR analysis of MTB-complex DNA in tissue samples taken during laparoscopy. Thus, the IGRA of ascites may guide the decision to start active treatment for tuberculosis.

PMID:: 19904487; [PubMed - indexed for MEDLINE]

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