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Nat Rev Neurosci. 2009 Dec;10(12):837-41. doi: 10.1038/nrn2726. Epub 2009 Nov 11.

Understanding microRNAs in neurodegeneration.

Author information

  • 1Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. tdawson@jhmi.edu

Abstract

Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.

PMID:
19904280
[PubMed - indexed for MEDLINE]
PMCID:
PMC4120241
Free PMC Article

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