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Pharmacol Rep. 2009 Sep-Oct;61(5):761-77.

Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system.

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  • 1Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Krak√≥w, Poland. filip@if-pan.krakow.pl


The present review gives an overview on the serotonin (5-hydroxytryptamine; 5-HT) system, its receptors and their relationship to central nervous system physiology and disorders. Additionally, we also introduce the recent knowledge about the 5-HT receptor ligands in preclinical research, clinical trials and as approved drugs.

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