J Am Chem Soc. 2009 Dec 2;131(47):17242-5.

A stereoselective approach to nucleosides and 4'-thioanalogues from acyclic precursors.

Chapdelaine D, Cardinal-David B, Prévost M, Gagnon M, Thumin I, Guindon Y.

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Institut de recherches cliniques de Montréal, Bio-organic Chemistry Laboratory, 110 avenue des Pins Ouest, Montréal, Québec, Canada H2W 1R7.

Abstract

D- and L-nucleosides and analogues thereof, including the 4'-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing the nucleobase, is described.

PMID:: 19902939; [PubMed - indexed for MEDLINE]

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A stereoselective approach to nucleosides and 4'-thioanalogues from acyclic precursors.

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