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Eur J Gynaecol Oncol. 2009;30(5):572-4.

Two cases of metachronic tumours: cancers of the ovary and endometrium in young women. Case presentation and review.

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  • 1Perinatology and Gynaecology Department, Poznan University of Medical Sciences, Poznan, Poland.


Ovarian and endometrial cancers seldom develop in females under 40 years of age. Manifestation of metachronic cancers before the age of 40 is of casuistic interest. Two cases are presented in whom metachronic cancers were detected: the first localisation involved the ovary, and the second the endometrium. One of the patients had earlier delivered a baby with multiple hereditary defects and was diagnosed with secondary infertility. The second patient was diagnosed with primary infertility. Immunohistochemical tests disclosed the presence of alpha and beta type estrogen receptors and progesterone receptors in the tumour cells of the ovary and endometrium. Neither of the patients carried mutations in the BRCA 1 or NOD 2 genes.

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