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FEBS Lett. 2010 Jan 21;584(2):405-12. doi: 10.1016/j.febslet.2009.11.002.

Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.

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  • 1Ecole Polytechnique, Laboratoire de Biochimie, F-91128 Palaiseau Cedex, France.


Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.

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