Format

Send to:

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2010 Jan 21;584(2):405-12. doi: 10.1016/j.febslet.2009.11.002.

Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.

Author information

  • 1Ecole Polytechnique, Laboratoire de Biochimie, F-91128 Palaiseau Cedex, France. emma@botrytis.polytechnique.fr

Abstract

Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.

PMID:
19896944
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk