FEBS Lett. 2010 Jan 21;584(2):405-12.

Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.

Source

Ecole Polytechnique, Laboratoire de Biochimie, F-91128 Palaiseau Cedex, France. emma@botrytis.polytechnique.fr

Abstract

Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.

PMID:: 19896944; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

tRNA binding properties of eukaryotic translation initiation factor 2 from Encephalitozoon cuniculi. [Biochemistry. 2010]
tRNA binding properties of eukaryotic translation initiation factor 2 from Encephalitozoon cuniculi.
Naveau M, Lazennec-Schurdevin C, Panvert M, Mechulam Y, Schmitt E. Biochemistry. 2010 Oct 12; 49(40):8680-8. Epub 2010 Sep 15.
The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors. [EMBO J. 2002]
The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors.
Schmitt E, Blanquet S, Mechulam Y. EMBO J. 2002 Apr 2; 21(7):1821-32.
Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states. [Proc Natl Acad Sci U S A. 2007]
Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states.
Yatime L, Mechulam Y, Blanquet S, Schmitt E. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18445-50. Epub 2007 Nov 13.
Review Translation initiation in Archaea: conserved and domain-specific features. [Biochem Soc Trans. 2011]
Review Translation initiation in Archaea: conserved and domain-specific features.
Benelli D, Londei P. Biochem Soc Trans. 2011 Jan; 39(1):89-93.
Review Eukaryotic type translation initiation factor 2: structure-functional aspects. [Biochemistry (Mosc). 2011]
Review Eukaryotic type translation initiation factor 2: structure-functional aspects.
Stolboushkina EA, Garber MB. Biochemistry (Mosc). 2011 Mar; 76(3):283-94.

See reviews... See all...

Cited by 4 PubMed Central articles

Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation. [J Biol Chem. 2012]
Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation.
Reid PJ, Mohammad-Qureshi SS, Pavitt GD. J Biol Chem. 2012 Mar 9; 287(11):8275-85. Epub 2012 Jan 11.
Integrated analyses of copy number variations and gene expression in lung adenocarcinoma. [PLoS One. 2011]
Integrated analyses of copy number variations and gene expression in lung adenocarcinoma.
Lu TP, Lai LC, Tsai MH, Chen PC, Hsu CP, Lee JM, Hsiao CK, Chuang EY. PLoS One. 2011; 6(9):e24829. Epub 2011 Sep 14.
eIF5 is a dual function GAP and GDI for eukaryotic translational control. [Small Gtpases. 2010]
eIF5 is a dual function GAP and GDI for eukaryotic translational control.
Jennings MD, Pavitt GD. Small Gtpases. 2010 Sep; 1(2):118-123.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA c...
Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.
FEBS Lett. 2010 Jan 21 ;584(2):405-12.

PubMed
Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-tri...
Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.
Biochem Pharmacol. 2010 Mar 15 ;79(6):864-72. Epub 2009 Nov 6 .

PubMed
Three methods tested to model SF-6D health utilities for health states involving...
Three methods tested to model SF-6D health utilities for health states involving comorbidity/co-occurring conditions.
J Clin Epidemiol. 2010 Mar ;63(3):331-41. Epub 2009 Nov 6 .

PubMed
Do statins cause myopathy by lowering vitamin E levels?
Do statins cause myopathy by lowering vitamin E levels?
Med Hypotheses. 2010 Apr ;74(4):707-9. Epub 2009 Nov 6 .

PubMed
Pronounced coronary artery calcification: casual finding in transthoracic echoca...
Pronounced coronary artery calcification: casual finding in transthoracic echocardiography.
Int J Cardiol. 2011 Jul 15 ;150(2):e53-4. Epub 2009 Nov 6 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: