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Head Face Med. 2009 Nov 9;5:22. doi: 10.1186/1746-160X-5-22.

The nature of fibrous dysplasia.

Author information

  • 1Department of Periodontology and Oral Medicine, University of Limpopo, Pretoria, South Africa. lfeller@ul.ac.za

Abstract

Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsalpha subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption.

PMID:
19895712
[PubMed - indexed for MEDLINE]
PMCID:
PMC2779176
Free PMC Article

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