The review discusses issues of multiple sclerosis (MS) management at the time of world-wide use of effective treatment - disease modifying treatment including the influence of the time of treatment start and adherence to treatment on its results, monitoring and treatment strategy of neurodegenerative disorders, problems of new trials, changes in MS course and significance of symptomatic treatment and rehabilitation. The discussion of many aspects is based on the data presented in the articles published in this special issue of the journal.