Diabetologia. 2010 Jan;53(1):10-20. Epub 2009 Nov 5.

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation.

Source

Hagedorn Research Institute, DK 2820 Gentofte, Denmark. hubert.kolb@gmx.com

Abstract

The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low-grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low-grade inflammation will eventually lead to overt diabetes if counter-regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter-regulatory response in predisposed individuals which is crucial to disease pathogenesis. Novel approaches of intervention may target these deficient defence mechanisms.

PMID:: 19890624; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Review Obesity, metabolic syndrome, and type 2 diabetes: inflammatory basis of glucose metabolic disorders. [Nutr Rev. 2007]
Review Obesity, metabolic syndrome, and type 2 diabetes: inflammatory basis of glucose metabolic disorders.
Pradhan A. Nutr Rev. 2007 Dec; 65(12 Pt 2):S152-6.
Review Healthy lifestyles in Europe: prevention of obesity and type II diabetes by diet and physical activity. [Public Health Nutr. 2001]
Review Healthy lifestyles in Europe: prevention of obesity and type II diabetes by diet and physical activity.
Astrup A. Public Health Nutr. 2001 Apr; 4(2B):499-515.
Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study. [Diabetologia. 2009]
Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study.
Herder C, Peltonen M, Koenig W, Sütfels K, Lindström J, Martin S, Ilanne-Parikka P, Eriksson JG, Aunola S, Keinänen-Kiukaanniemi S, et al. Diabetologia. 2009 Mar; 52(3):433-42. Epub 2009 Jan 8.
Review Impaired glucose regulation and type 2 diabetes in children and adolescents. [Diabetes Metab Res Rev. 2008]
Review Impaired glucose regulation and type 2 diabetes in children and adolescents.
Kempf K, Rathmann W, Herder C. Diabetes Metab Res Rev. 2008 Sep; 24(6):427-37.
Review [Trends in diabetes mellitus in Brazil: the role of the nutritional transition]. [Cad Saude Publica. 2003]
Review [Trends in diabetes mellitus in Brazil: the role of the nutritional transition].
Sartorelli DS, Franco LJ. Cad Saude Publica. 2003; 19 Suppl 1:S29-36. Epub 2003 Jul 21.

See reviews... See all...

Cited by 3 PubMed Central articles

Improved glycemic control without hypoglycemia in elderly diabetic patients using the ubiquitous healthcare service, a new medical information system. [Diabetes Care. 2011]
Improved glycemic control without hypoglycemia in elderly diabetic patients using the ubiquitous healthcare service, a new medical information system.
Lim S, Kang SM, Shin H, Lee HJ, Won Yoon J, Yu SH, Kim SY, Yoo SY, Jung HS, Park KS, et al. Diabetes Care. 2011 Feb; 34(2):308-13.
Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. [Mol Vis. 2010]
Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis.
Suzuki M, Noda K, Kubota S, Hirasawa M, Ozawa Y, Tsubota K, Mizuki N, Ishida S. Mol Vis. 2010 Jul 17; 16:1382-8. Epub 2010 Jul 17.
Prevalence rate of diabetes mellitus and impaired fasting glycemia in Hungary: cross-sectional study on nationally representative sample of people aged 20-69 years. [Croat Med J. 2010]
Prevalence rate of diabetes mellitus and impaired fasting glycemia in Hungary: cross-sectional study on nationally representative sample of people aged 20-69 years.
Jermendy G, Nádas J, Szigethy E, Széles G, Nagy A, Hídvégi T, Paragh G, Adány R. Croat Med J. 2010 Apr; 51(2):151-6.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inf...
The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation.
Diabetologia. 2010 Jan ;53(1):10-20. Epub 2009 Nov 5 .

PubMed
Mothers' Intentions to Teach Adolescent Daughters about Breast Cancer Risk Reduc...
Mothers' Intentions to Teach Adolescent Daughters about Breast Cancer Risk Reduction Activities: The Influence of Self-Efficacy, Response Efficacy, & Personal Responsibility.
Commun Res Rep. 2009 Apr 1;26(2):134-145.

PubMed
Compensating for Non-Stationary Blurring by Further Blurring and Deconvolution.
Compensating for Non-Stationary Blurring by Further Blurring and Deconvolution.
Int J Imaging Syst Technol. 2009 Sep 1;19(3):221-226.

PubMed
Vaccination against classical influenza in health-care workers: self-protection ...
Vaccination against classical influenza in health-care workers: self-protection and patient protection.
Dtsch Arztebl Int. 2009 Sep ;106(36):567-72. Epub 2009 Sep 4 .

PubMed
Deep sequencing of viroid-derived small RNAs from grapevine provides new insight...
Deep sequencing of viroid-derived small RNAs from grapevine provides new insights on the role of RNA silencing in plant-viroid interaction.
PLoS One. 2009 Nov 5 ;4(11):e7686.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information