Topiramate overdose: a case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticus

Epilepsia. 2010 Jun;51(6):1090-3. doi: 10.1111/j.1528-1167.2009.02395.x. Epub 2009 Nov 3.

Abstract

We report the case of a 21-year-old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. On admission to the hospital he had a nonconvulsive status epilepticus and received 4 mg lorazepam i.v. He recovered rapidly despite an initial TPM concentration of 144.6 microg/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Overdose
  • Fructose / analogs & derivatives*
  • Fructose / blood
  • Fructose / poisoning
  • Humans
  • Male
  • Status Epilepticus / blood*
  • Status Epilepticus / chemically induced
  • Status Epilepticus / diagnosis
  • Suicide, Attempted*
  • Topiramate
  • Young Adult

Substances

  • Topiramate
  • Fructose