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Mol Syst Biol. 2009;5:320. doi: 10.1038/msb.2009.77. Epub 2009 Nov 3.

Applications of genome-scale metabolic reconstructions.

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  • 1Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, VA, USA.


The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.

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