AIDS Res Hum Retroviruses. 2009 Nov;25(11):1165-9.

HIV type 1 subtype A envelope genetic evolution in a slow progressing individual with consistent broadly neutralizing antibodies.

Dieltjens T, Loots N, Vereecken K, Grupping K, Heyndrickx L, Bottieau E, Vanham G, Davis D, Janssens W.

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Department of Microbiology, Unit of Virology, Institute of Tropical Medicine, Antwerp, Belgium. tdieltjens@itg.be

Abstract

Studies of viruses taken from individuals with broad cross-neutralizing antibodies against primary isolates may reveal novel antibody specificities and their associated epitopes that could be useful for immunogen design. We report on the Env antigenic variability of a slow progressing HIV-1 subtype A-infected donor with consistent broad cross-neutralizing antibodies during the second decade of disease progression after vertical transmission. The Env evolution is characterized by a genetic shift to variants with altered V1-V5 loop sequences, marked by consecutive changes in V1, V4-V5, and C3 and largely conserved V2 and V3 loop sequences. Major V1 Env sequence expansion, variation by a duplication event, and cumulative addition of cysteine residues and potential N-glycosylation sites over time may contribute to escape from antibody pressure directed to Env receptor domains by changing the exposure of neutralization-sensitive epitopes. Conservation of functional epitopes may correlate with the continued presence of broad cross-neutralizing antibodies.

PMID:: 19886837; [PubMed - indexed for MEDLINE]

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