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Annu Rev Genet. 2009;43:525-58. doi: 10.1146/annurev-genet-102108-134233.

Cohesin: its roles and mechanisms.

Author information

  • 1Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom. kim.nasmyth@bioch.ox.ac.uk

Abstract

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

PMID:
19886810
[PubMed - indexed for MEDLINE]
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