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Microbes Infect. 2010 Feb;12(2):89-98. doi: 10.1016/j.micinf.2009.10.002. Epub 2009 Oct 31.

Molecular mechanisms of enterotoxigenic Escherichia coli infection.

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  • 1Medicine Service Veterans Affairs Medical Center, Memphis, TN 38104, USA. jflecke1@tennessee.edu

Abstract

Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.

Published by Elsevier SAS.

PMID:
19883790
[PubMed - indexed for MEDLINE]
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