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Mol Cell Endocrinol. 2010 May 28;321(1):44-9. doi: 10.1016/j.mce.2009.10.009. Epub 2009 Oct 31.

Rearrangements of NTRK1 gene in papillary thyroid carcinoma.

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  • 1Department of Experimental Oncology and Laboratory, Operative Unit 3 Molecular Mechanisms of Cancer Growth and Progression, Fondazione IRCCS - Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milan, Italy. angela.greco@istitutotumori.mi.it

Abstract

TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.

Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

PMID:
19883730
[PubMed - indexed for MEDLINE]
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