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    Int J Infect Dis. 2010 Feb;14(2):e167-70. Epub 2009 Oct 31.

    Disseminated Mycobacterium scrofulaceum infection in a child with interferon-gamma receptor 1 deficiency.

    Marazzi MG, Chapgier A, Defilippi AC, Pistoia V, Mangini S, Savioli C, Dell'Acqua A, Feinberg J, Tortoli E, Casanova JL.

    Source

    Infectious Unit and University of Genoa, G. Gaslini Scientific Institute, Largo G. Gaslini 5, 16147 Genoa, Italy. mgmarazzi@ospedale-gaslini.ge.it

    Abstract

    Disseminated disease caused by non-tuberculous, environmental mycobacteria (EM) reflects impaired host immunity. Disseminated disease caused by Mycobacterium scrofulaceum has primarily been reported in patients with AIDS. Moreover, observing M. scrofulaceum as the agent of localized disease in childhood has become increasingly rare. We report the first case of disseminated disease caused by M. scrofulaceum in a child with inherited interferon-gamma receptor 1 (IFN-gammaR1) complete deficiency. As in this case, mycobacterial bone infections in IFN-gammaR1 deficiency can sometimes mimic the clinical picture of chronic recurrent multifocal osteomyelitis.

    Copyright 2009. Published by Elsevier Ltd.

    PMID:
    19880337
    [PubMed - indexed for MEDLINE]

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