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    Antiviral Res. 2010 Feb;85(2):346-53. doi: 10.1016/j.antiviral.2009.10.014. Epub 2009 Oct 30.

    Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus.

    Sui X, Yin J, Ren X.

    Source

    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, 150030 Harbin, China.

    Abstract

    Diammonium glycyrrhizin (DG), a salt from glycyrrhizinate (GL) that is a major active component of licorice root extract with various pharmacological activities was investigated for its inhibitory effect on pseudorabies virus (PrV) infection. In parallel, lithium chloride (LiCl), a chemical reagent with potential antiviral activity was compared with DG for their inhibitory ability against PrV infection in vitro. Virus plaque-reduction assays, PCR and RT-PCR analysis indicated that both drugs inhibited cell infection by PrV. Moreover, addition of the drugs resulted in fewer apoptotic cells during PrV infection.

    Copyright 2009 Elsevier B.V. All rights reserved.

    PMID:
    19879899
    [PubMed - indexed for MEDLINE]

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