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FEBS Lett. 2009 Dec 3;583(23):3872-9. doi: 10.1016/j.febslet.2009.10.066. Epub 2009 Oct 29.

Toward a model for Arf GTPases as regulators of traffic at the Golgi.

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  • Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd., Atlanta, GA 30322, USA. rkahn@emory.edu


In this review, I summarize the likely roles played by ADP-ribosylation factor (Arf) proteins in the regulation of membrane traffic at the Golgi, from the perspective of the GTPase. The most glaring limitations to the development of a coherent molecular model are highlighted; including incomplete information on the initiation of Arf activation, identification of the "accessory proteins" required for carrier maturation and scission, and those required for directed traffic and fusion at the destination membrane. Though incomplete, the molecular model of carrier biogenesis has developed rapidly in recent years and promises richness in understanding this essential process.

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