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FEBS Lett. 2009 Dec 3;583(23):3857-62. doi: 10.1016/j.febslet.2009.10.077. Epub 2009 Oct 29.

Mitotic inheritance of the Golgi complex.

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  • 1Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Chieti), Italy.

Abstract

In mammals, the Golgi complex is structured in the form of a continuous membranous system composed of stacks connected by tubular bridges, the "Golgi ribbon". At the onset of mitosis, the Golgi complex undergoes a multi-step fragmentation process that is required for its correct partition into the dividing cells. Regulation of Golgi fragmentation and cell cycle progression appear to be precisely coordinated. Here, we review recent studies that are revealing the fundamental mechanisms, the molecular players and the biological significance of the mitotic inheritance of the Golgi complex in mammalian cells.

PMID:
19879264
[PubMed - indexed for MEDLINE]
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