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    Cancer Cell. 2009 Nov 6;16(5):366-8.

    PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer.

    Fearon ER.

    Source

    Division of Molecular Medicine & Genetics, Departments of Internal Medicine, Human Genetics and Pathology, and The Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-22200, USA. fearon@umich.edu

    Abstract

    Genetic alternations resulting in constitutive stabilization of beta-catenin and altered transcription of beta-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers insights into the role of tankyrase in regulating the Wnt/beta-catenin pathway and suggests that compounds targeting tankyrase's poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy.

    PMID:
    19878868
    [PubMed - indexed for MEDLINE]

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