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Endocr Res. 2009;34(4):121-9. doi: 10.3109/07435800903228909.

Outcome after high-dose radioiodine therapy for advanced differentiated thyroid carcinoma in childhood.

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  • 1Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Abstract

OBJECTIVE:

To evaluate the clinical outcome in childhood patients receiving postoperative high-dose radioiodine therapy for advanced differentiated thyroid carcinoma.

METHOD:

Patients under 18 years old with neck diseases (n = 4) or distant metastases (n = 10) received postoperative radioiodine ablation and repeated treatments for a median of 2 (0.8 10) years with an averaged activity of 25.0 (7.0 72.2) GBq.

RESULTS:

Partial remission was achieved in 6, stable disease in 6 and progressive disease in 2 patients, without severe side effects except for two Grade 1 and one Grade 2 WHO haematological toxicity. The median survival time from diagnosis to the last treatment sessions was 5.3 (range, 0.7 14.5) years.

CONCLUSION:

High-dose radioiodine treatment was well tolerated with satisfactory outcome in childhood patients with advanced differentiated thyroid carcinoma.

PMID:
19878072
[PubMed - indexed for MEDLINE]
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