(A) EMT regulation by miRNAs: miRNAs such as miR-200 and miR-205, modulate the ZEB family of transcription factors and regulate epithelial-mesenchymal transition. miR-101 modulates E-cadherin expression epigenetically via targeting Zeste Homolog 2 (EZH2) in prostate cancer. miR-155 modulates TGFβ pathway, which plays an important role in cancer metastasis. (B) Suppression of metastasis by miRNAs:. miR-10b is the first miRNA identified to be upregulated in breast cancer that is mediated by Twist1, MMPs, urokinase plasminogen activator(uPA), and various integrins. miR-373 and miR-520c are pro-metastatic miRNAs that serve as metastasis promoters (partly mediated by modulation of CD44). miR-335, miR-206 and miR-31 are identified as antimetastatic miRNAs that target RhoA, Fzd3, RDX, and integrin α5. miR-146 and miR-98/let-7 are shown to be upregulated in response to metastatic suppressor proteins BRMS-1 and RKIP respectively. miR-10b, miR-373, miR-520c and miR-21 are pro-metastatic miRNAs, while miRNAs such as miR-335, miR-206 and miR-31 are anti-metastatic. Prometastatic miRNAs are depicted pink, dark green and red, while anti-metastatic ones are shown in violet, red and light green.