Eur J Immunol. 2010 Jan;40(1):113-6. doi: 10.1002/eji.200939371.

Long-lasting immunity by early infection of maternal-antibody-protected infants.

Navarini AA, Krzyzowska M, Lang KS, Horvath E, Hengartner H, Niemialtowski MG, Zinkernagel RM.

Source

Institute for Experimental Immunology, University Hospital Zürich, Zürich, Switzerland. alexander.navarini@usz.ch

Abstract

Newborn higher vertebrates are largely immuno-incompetent and generally survive infections--including poxviruses--by maternal antibody protection. Here, we show that mice survived epidemics as adults only if exposed to lethal orthopoxvirus infections during infancy under the umbrella of maternal protective antibodies. This implies that both the absence of exposure to infection during early infancy or of effective vaccination renders the population highly susceptible to new or old re-emerging pathogens.

PMID:: 19877011; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Antibodies, Viral

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Maternal immunization with both hemagglutinin- and neuraminidase-expressing DNAs provides an enhanced protection against a lethal influenza virus challenge in infant and adult mice. [DNA Cell Biol. 2005]
Maternal immunization with both hemagglutinin- and neuraminidase-expressing DNAs provides an enhanced protection against a lethal influenza virus challenge in infant and adult mice.
Zhang F, Chen J, Fang F, Zhou Y, Wu J, Chang H, Zhang R, Wang F, Li X, Wang H, et al. DNA Cell Biol. 2005 Nov; 24(11):758-65.
[The resistance of a maternally-derived immunity of baby mice against mousepox--experiments regarding a special possibility of immunization with orthopox viruses (author's transl)]. [Zentralbl Bakteriol B. 1979]
[The resistance of a maternally-derived immunity of baby mice against mousepox--experiments regarding a special possibility of immunization with orthopox viruses (author's transl)].
Munz E, Reimann M, Kaufmann R. Zentralbl Bakteriol B. 1979; 169(5-6):495-509.
Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. [J Virol. 2006]
Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function.
Panchanathan V, Chaudhri G, Karupiah G. J Virol. 2006 Jul; 80(13):6333-8.
Review The inflammatory and immune response to mousepox (infectious ectromelia) virus. [Acta Virol. 1994]
Review The inflammatory and immune response to mousepox (infectious ectromelia) virus.
Niemiałtowski MG, Spohr de Faundez I, Gieryńska M, Malicka E, Toka FN, Schollenberger A, Popis A. Acta Virol. 1994 Oct; 38(5):299-307.
Review Passive protection against respiratory syncytial virus disease in infants: the role of maternal antibody. [Pediatr Infect Dis J. 1994]
Review Passive protection against respiratory syncytial virus disease in infants: the role of maternal antibody.
Englund JA. Pediatr Infect Dis J. 1994 May; 13(5):449-53.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Long-lasting immunity by early infection of maternal-antibody-protected infants.
Long-lasting immunity by early infection of maternal-antibody-protected infants.
Eur J Immunol. 2010 Jan ;40(1):113-6. doi: 10.1002/eji.200939371.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: