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    J Biol Chem. 2009 Dec 25;284(52):36118-27. Epub 2009 Oct 28.

    A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans.

    Reilly MC, Levery SB, Castle SA, Klutts JS, Doering TL.

    Source

    Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

    Abstract

    Cryptococcus neoformans is a fungal pathogen that causes serious disease in immunocompromised individuals. The organism produces a distinctive polysaccharide capsule that is necessary for its virulence, a predominantly polysaccharide cell wall, and a variety of protein- and lipid-linked glycans. The glycan synthetic pathways of this pathogen are of great interest. Here we report the detection of a novel glycosylphosphotransferase activity in C. neoformans, identification of the corresponding gene, and characterization of the encoded protein. The observed activity is specific for UDP-xylose as a donor and for mannose acceptors and forms a xylose-alpha-1-phosphate-6-mannose linkage. This is the first report of a xylosylphosphotransferase activity in any system.

    PMID:
    19864415
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2794727
    Free PMC Article

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