Mutat Res. 1991 Jan;262(1):21-3.

Replication intermediates as substrates for DNA rearrangements.

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Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143-0750.

Abstract

A model for the formation of DNA rearrangements in somatic cells is presented. Two double-strand breaks at the junctions between unreplicated DNA and newly replicated DNA generate four double-stranded DNA molecules that can recombine to form tandem duplications, inversions, deletions and extrachromosomal DNA circles.

PMID:: 1986280; [PubMed - indexed for MEDLINE]

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DNA, Circular

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Replication intermediates as substrates for DNA rearrangements.

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Cited by 1 PubMed Central article

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