Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Prenat Diagn. 2009 Dec;29(13):1244-8. doi: 10.1002/pd.2397.

First trimester pregnancy associated plasma protein-A as a marker for poor pregnancy outcome in patients with early-onset fetal growth restriction.

Author information

  • 1Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, NY 10128, USA. nfox@mfmnyc.com

Abstract

OBJECTIVE:

To determine whether pregnancy associated plasma protein-A (PAPP-A) can be used to identify pregnancies at risk for poor perinatal outcomes among patients with second trimester fetal growth restriction (FGR).

METHODS:

We analyzed outcomes for singleton pregnancies of patients with evidence of FGR in the second trimester who also had first trimester serum PAPP-A measured for aneuploidy risk assessment. We excluded pregnancies with aneuploidy, major anomalies, fetal infection, or second trimester premature rupture of membranes (PPROM).

RESULTS:

One hundred and ninety eight pregnancies with second trimester FGR and first trimester serum PAPP-A measurements were identified. PAPP-A below the fifth percentile was associated with an increased rate of third trimester SGA (50% vs 11%, p = 0.012), preterm birth (33.3% vs 8%, p = 0.039), NICU admission (33.3% vs 8%, p = 0.039), intrauterine or neonatal death (20% vs 0%, p = 0.002), smaller median birth weight (2975g vs 3085g, p = 0.026), and earlier median gestational age at delivery (38.14 weeks vs 39.86 weeks, p = 0.004). PAPP-A values below the 10th percentile and below the 25th percentile were also associated with poor outcomes.

CONCLUSION:

PAPP-A appears to be a useful marker for neonatal outcome in patients diagnosed with second trimester FGR.

Copyright (c) 2009 John Wiley & Sons, Ltd.

PMID:
19862778
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk