J Org Chem. 2009 Nov 20;74(22):8897-900.

Zinc chloride-promoted aryl bromide-alkyne cross-coupling reactions at room temperature.

Finke AD, Elleby EC, Boyd MJ, Weissman H, Moore JS.

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Department of Chemistry, University of Illinois Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

Abstract

Substoichiometric amounts of ZnCl(2) promote the room temperature, Pd/P(t-Bu)(3)-catalyzed cross-coupling of aryl bromides with alkynes. Pd(I) dimer 1 is demonstrated to be a particularly active precatalyst for this reaction. The reaction is general for a wide variety of aryl bromides.

PMID:: 19860393; [PubMed - indexed for MEDLINE]

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