Bioorg Med Chem Lett. 2009 Dec 1;19(23):6524-8. doi: 10.1016/j.bmcl.2009.10.054. Epub 2009 Oct 24.

Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.

Ioannidis S, Lamb ML, Davies AM, Almeida L, Su M, Bebernitz G, Ye M, Bell K, Alimzhanov M, Zinda M.

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Department of Cancer Chemistry, AstraZeneca R&D Boston, Waltham, MA 02451, USA. Stephanos.Ioannidis@astrazeneca.com

Abstract

The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds.

PMID:: 19857966; [PubMed - indexed for MEDLINE]

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Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Bioorg Med Chem Lett. 2009 Dec 1 ;19(23):6524-8. doi: 10.1016/j.bmcl.2009.10.054. Epub 2009 Oct 24 .

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