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Nat Rev Nephrol. 2009 Nov;5(11):611-2. doi: 10.1038/nrneph.2009.168.

Transplantation: time to rethink immunosuppression by mTOR inhibitors?

Abstract

Several surprising findings indicate that pharmacological blocking of the multifunctional enzyme mTor fosters distinct differentiation programs in different immunocompetent cells. These data might lead to a striking change in our view of the role that mTor inhibition should have in immunosuppressive therapy for allogeneic transplant recipients.

PMID:
19855420
[PubMed - indexed for MEDLINE]
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