Development. 2009 Nov;136(22):3699-714.

The regulation of TGFbeta signal transduction.

Source

Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden. aris.moustakas@licr.uu.se

Abstract

Transforming growth factor beta (TGFbeta) pathways are implicated in metazoan development, adult homeostasis and disease. TGFbeta ligands signal via receptor serine/threonine kinases that phosphorylate, and activate, intracellular Smad effectors as well as other signaling proteins. Oligomeric Smad complexes associate with chromatin and regulate transcription, defining the biological response of a cell to TGFbeta family members. Signaling is modulated by negative-feedback regulation via inhibitory Smads. We review here the mechanisms of TGFbeta signal transduction in metazoans and emphasize events crucial for embryonic development.

PMID:: 19855013; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Transforming Growth Factor beta

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. [J Biol Chem. 2009]
Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling.
Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R. J Biol Chem. 2009 Mar 6; 284(10):6291-300. Epub 2008 Dec 15.
Review [Cellular signaling in response to TGFbeta: the paradox of a factor that blocks cell proliferation and enhances metastasis]. [Bull Cancer. 1999]
Review [Cellular signaling in response to TGFbeta: the paradox of a factor that blocks cell proliferation and enhances metastasis].
Vignais ML. Bull Cancer. 1999 Nov; 86(11):903-10.
Review Regulating the stability of TGFbeta receptors and Smads. [Cell Res. 2009]
Review Regulating the stability of TGFbeta receptors and Smads.
Lönn P, Morén A, Raja E, Dahl M, Moustakas A. Cell Res. 2009 Jan; 19(1):21-35.
Review Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. [Oncogene. 2004]
Review Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation.
Izzi L, Attisano L. Oncogene. 2004 Mar 15; 23(11):2071-8.
Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway. [J Biol Chem. 2007]
Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.
Lee BH, Chen W, Stippec S, Cobb MH. J Biol Chem. 2007 Jun 22; 282(25):17985-96. Epub 2007 Mar 28.

See reviews... See all...

Cited by 38 PubMed Central articles

Transcription Factor FoxO1 Is Essential for Enamel Biomineralization. [PLoS One. 2012]
Transcription Factor FoxO1 Is Essential for Enamel Biomineralization.
Poché RA, Sharma R, Garcia MD, Wada AM, Nolte MJ, Udan RS, Paik JH, Depinho RA, Bartlett JD, Dickinson ME. PLoS One. 2012; 7(1):e30357. Epub 2012 Jan 24.
Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing. [Front Physiol. 2011]
Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing.
Valluru M, Staton CA, Reed MW, Brown NJ. Front Physiol. 2011; 2:89. Epub 2011 Nov 29.
HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling. [Cell Death Dis. 2011]
HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling.
Goto K, Tong KI, Ikura J, Okada H. Cell Death Dis. 2011 Dec 1; 2:e236. Epub 2011 Dec 1.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The regulation of TGFbeta signal transduction.
The regulation of TGFbeta signal transduction.
Development. 2009 Nov ;136(22):3699-714.

PubMed
STIM1: a novel phosphoprotein located at the cell surface.
STIM1: a novel phosphoprotein located at the cell surface.
Biochim Biophys Acta. 2000 Aug 31 ;1481(1):147-55.

PubMed
On the unique function of selenocysteine - insights from the evolution of seleno...
On the unique function of selenocysteine - insights from the evolution of selenoproteins.
Biochim Biophys Acta. 2009 Nov ;1790(11):1463-70. Epub 2009 Apr 1 .

PubMed
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry.
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry.
Curr Biol. 2006 Jul 25 ;16(14):1465-70.

PubMed
Pharmacogenomics and the drug discovery pipeline: when should it be implemented?
Pharmacogenomics and the drug discovery pipeline: when should it be implemented?
Am J Pharmacogenomics. 2005 ;5(1):53-62.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: