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Curr Opin Pharmacol. 2009 Dec;9(6):697-701. doi: 10.1016/j.coph.2009.10.004. Epub 2009 Oct 24.

The role of neutrophils in the event of intestinal inflammation.

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  • 1The Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA.


The transmigration of polymorphonuclear leukocytes (PMNs; neutrophils) into the intestinal lumen is a classical phenomenon associated with a wide variety of disease states, including those of both pathogenic and autoimmune/idiopathic origin. While PMNs are highly effective at killing invading pathogens by releasing microbiocidal products, excessive or unnecessary release of these substances can cause substantial damage to the intestinal epithelium. Therefore, it is necessary to understand the underlying mechanisms that lure neutrophils into the lumen allowing them to perform their desired functions, so that researchers may begin to identify which processes may be potential targets for inhibiting the transmigration of PMNs during noninfectious states.

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