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Resuscitation. 2010 Jan;81(1):9-14. doi: 10.1016/j.resuscitation.2009.09.015. Epub 2009 Oct 24.

A randomized controlled trial comparing the Arctic Sun to standard cooling for induction of hypothermia after cardiac arrest.

Author information

  • 1University of Colorado Denver School of Medicine and the Colorado Emergency Medicine Research Center, Denver, CO, United States. kennon.heard@ucdenver.edu

Abstract

CONTEXT:

Hypothermia improves neurological outcome for comatose survivors of out-of-hospital cardiac arrest. Use of computer controlled high surface area devices for cooling may lead to faster cooling rates and potentially improve patient outcome.

OBJECTIVE:

To compare the effectiveness of surface cooling with the standard blankets and ice packs to the Arctic Sun, a mechanical device used for temperature management.

DESIGN, SETTING, AND PATIENTS:

Multi-center randomized trial of hemodynamically stable comatose survivors of out-of-hospital cardiac arrest.

INTERVENTION:

Standard post-resuscitative care inducing hypothermia using cooling blankets and ice (n=30) or the Arctic Sun (n=34).

MAIN OUTCOME MEASURES:

The primary end point was the proportion of subjects who reached a target temperature within 4h of beginning cooling. The secondary end points were time interval to achieve target temperature (34 degrees C) and survival to 3 months.

RESULTS:

The proportion of subjects cooled below the 34 degrees C target at 4h was 71% for the Arctic Sun group and 50% for the standard cooling group (p=0.12). The median time to target was 54 min faster for cooled patients in the Arctic Sun group than the standard cooling group (p<0.01). Survival rates with good neurological outcome were similar; 46% of Arctic Sun patients and 38% of standard patients had a cerebral performance category of 1 or 2 at 30 days (p=0.6).

CONCLUSIONS:

While the proportion of subjects reaching target temperature within 4h was not significantly different, the Arctic Sun cooled patients to a temperature of 34 degrees C more rapidly than standard cooling blankets.

Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

PMID:
19854555
[PubMed - indexed for MEDLINE]
PMCID:
PMC2815241
Free PMC Article

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