Am J Clin Nutr. 1991 Jan;53(1 Suppl):358S-361S.

Assessment of the roles of vitamin C, vitamin E, and beta-carotene in the modulation of oxidant stress mediated by cigarette smoke-activated phagocytes.

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Department of Immunology, Institute for Pathology, University of Pretoria, Republic of South Africa.

Abstract

Phagocyte-derived reactive oxidants have been increasingly implicated in inflammation-related tissue injury and carcinogenesis. Cigarette smoking is a useful human model of chronic inflammation since it is uncomplicated by chemotherapy. It has been utilized to investigate both the involvement of phagocyte-derived reactive oxidants in the pathogenesis of pulmonary dysfunction and carcinogenesis, as well as the possible role of nutritional antioxidants in the prevention of oxidant-mediated tissue damage. Reactive oxidants generated by activated phagocytes appear to be primary mediators of spirometric abnormalities in cigarette smokers. Cigarette smoking is also associated with decreased plasma levels of ascorbate and beta-carotene, which indicates that the smoking-related chronic inflammatory response leads to an imbalance of oxidant/antioxidant homeostasis and possible predisposition to oxidant-inflicted tissue damage and disease.

PMID:: 1985411; [PubMed - indexed for MEDLINE]

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Investigation of the role of phagocytes and anti-oxidant nutrients in oxidant stress mediated by cigarette smoke. [Int J Vitam Nutr Res. 1990]
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Cited by 3 PubMed Central articles

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Effects of acute cigarette smoke exposure on macrophage kinetics and release of tumour necrosis factor alpha in rats.
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