Neurology. 1991 Jan;41(1):20-5.

The efficacy of azathioprine in relapsing-remitting multiple sclerosis.

Goodkin DE, Bailly RC, Teetzen ML, Hertsgaard D, Beatty WW.

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Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, OH 44195-5244.

Abstract

We randomized 59 patients with relapsing-remitting multiple sclerosis to receive azathioprine (AZA) 3.0 mg/kg daily or placebo in a double-masked therapeutic trial. Analysis of data for predetermined primary outcome measures demonstrated a significant difference favoring AZA for observed mean exacerbation rate after 2 years of therapy and time to deterioration in both Ambulation Index and Kurtzke Expanded Disability Status Scale score. This study confirms a modest therapeutic benefit for azathioprine previously reported by other investigators.

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