Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biochemistry. 2009 Nov 24;48(46):10827-9. doi: 10.1021/bi901680m.

Enterobactin synthetase-catalyzed formation of P(1),P(3)-diadenosine-5'-tetraphosphate.

Author information

  • 1Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Abstract

The EntE enzyme, involved in the synthesis of the iron siderophore enterobactin, catalyzes the adenylation of 2,3-dihydroxybenzoic acid, followed by its transfer to the phosphopantetheine arm of holo-EntB, an aryl carrier protein. In the absence of EntB, EntE catalyzes the formation of Ap(4)A, a molecule that is implicated in regulating cell division during oxidative stress. We propose that the expression of EntE during iron starvation produces Ap(4)A to slow growth until intracellular iron stores can be restored.

PMID:
19852513
[PubMed - indexed for MEDLINE]
PMCID:
PMC2783875
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society Icon for PubMed Central
    Loading ...
    Write to the Help Desk