Abstract
Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Atlases as Topic
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Brain / anatomy & histology
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Brain / metabolism*
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Brain Chemistry / physiology
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Brain Mapping
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Capillaries / cytology
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Capillaries / metabolism
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism*
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Cation Transport Proteins / metabolism
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Ceruloplasmin / metabolism
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Choroid Plexus / cytology
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Choroid Plexus / metabolism*
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Epithelial Cells / metabolism
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Ferritins / metabolism
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Gene Expression / physiology
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Homeostasis / physiology*
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Iron / metabolism*
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Magnetic Resonance Imaging
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Mice
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RNA, Messenger / metabolism
Substances
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Carrier Proteins
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Cation Transport Proteins
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RNA, Messenger
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metal transporting protein 1
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solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2
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Ferritins
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Iron
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Ceruloplasmin