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Trends Genet. 2009 Dec;25(12):519-22. doi: 10.1016/j.tig.2009.10.001. Epub 2009 Oct 21.

Monoallelic expression and tissue specificity are associated with high crossover rates.

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  • 1Université de Lyon, Lyon, France. necsulea@biomserv.univ-lyon1.fr


What determines the recombination rate of a gene? Following the observation that, in humans, imprinted genes have unusually high recombination levels, we ask whether increased recombination is seen for other monoallelically expressed genes and, more generally, how transcriptional properties relate to recombination. We find that monoallelically expressed genes do have high crossover rates and discover a striking negative correlation between within-gene crossover rate and expression breadth. We hypothesise that these findings are possibly symptomatic of a more general, adverse relationship between recombination and transcription in the human genome.

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