J Cell Physiol. 2010 Feb;222(2):282-5.

The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells.

Source

Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan.

Abstract

Lineage-specific transcription factors must be precisely regulated during stem cell self-renewal and lineage commitment decisions. The role of specific transcription factors in hematopoietic stem cell (HSC) fate decisions has derived largely from genetic strategies, primarily gene-targeting and transgenic or retroviral overexpression experiments. From the previous experimental results, several transcription factors have been found to play critical roles in HSC physiology. Among them, we focus two transcription factors, Runx1/AML1 and Evi-1, in this review. During embryogenesis, both Runx1 and Evi-1 are essential for HSCs whereas in the adult, Runx1 and Evi-1 regulate HSCs negatively and positively, respectively.

2009 Wiley-Liss, Inc.

PMID:: 19847803; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Stem Cells - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. [Cell Stem Cell. 2008]
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.
Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M. Cell Stem Cell. 2008 Aug 7; 3(2):207-20.
Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo. [Stem Cells. 2004]
Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo.
Schuringa JJ, Wu K, Morrone G, Moore MA. Stem Cells. 2004; 22(7):1191-204.
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. [Exp Hematol. 2010]
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells.
Challen GA, Goodell MA. Exp Hematol. 2010 May; 38(5):403-16. Epub 2010 Mar 3.
Review Evi-1 as a critical regulator of leukemic cells. [Int J Hematol. 2010]
Review Evi-1 as a critical regulator of leukemic cells.
Goyama S, Kurokawa M. Int J Hematol. 2010 Jun; 91(5):753-7. Epub 2010 Jun 8.
Review Molecular mechanisms of leukemogenesis by AML1/EVI-1. [Oncogene. 2004]
Review Molecular mechanisms of leukemogenesis by AML1/EVI-1.
Mitani K. Oncogene. 2004 May 24; 23(24):4263-9.

See reviews... See all...

Cited by 1 PubMed Central article

Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line. [PLoS Genet. 2012]
Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line.
Wu JQ, Seay M, Schulz VP, Hariharan M, Tuck D, Lian J, Du J, Shi M, Ye Z, Gerstein M, et al. PLoS Genet. 2012 Mar; 8(3):e1002565. Epub 2012 Mar 8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells.
The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells.
J Cell Physiol. 2010 Feb ;222(2):282-5.

PubMed
Use of the pinch strength meter in tender point examination.
Use of the pinch strength meter in tender point examination.
Arthritis Rheum. 1991 Jan ;34(1):128.

PubMed
Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chines...
Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.
Planta Med. 2010 Mar ;76(5):439-43. Epub 2009 Oct 21 .

PubMed
A blood lead benchmark for assessing risks from childhood lead exposure.
A blood lead benchmark for assessing risks from childhood lead exposure.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2009 Oct ;44(12):1200-8.

PubMed
Does physical activity modify the risk of obesity for type 2 diabetes: a review ...
Does physical activity modify the risk of obesity for type 2 diabetes: a review of epidemiological data.
Eur J Epidemiol. 2010 ;25(1):5-12. Epub 2009 Oct 22 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information